Glutathione S-transferases Detoxify Endogenous and Exogenous Toxic Agents- Minireview
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چکیده
منابع مشابه
Glutathione S-transferases Detoxify Endogenous and Exogenous Toxic Agents- Minireview
The biotransformation of foreign substances (xenobiotic) including drugs in the body is divided into phase I, II and III. But phase II enzymes are playing a key role in the biotransformation of endogenous compounds and xenobiotics to easily excretable forms and also the metabolic inactivation of pharmacologically active substances. The phase II enzymes can perform biotransformation through conj...
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Class-Pi of glutathione s-transferases (GST-Pi) is the specific form of GSTs that are known to participate particularly in the mechanisms of resistance to drugs and carcinogens. This class of the enzyme is referred to as class-P or class-Pi or class π. The accepted terminology in this review article is class-Pi. In this article following a brief description of identified molecular forms of GSTs...
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Background: The glutathione S-transferase (GST) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. The expression of many of these cancer susceptibility enzymes is genetically polymorphic. An increased frequency of GST-null genotypes has been associated with several malignancies. Objective: To investigate the rate of GSTT1 and GSTM1 null ge...
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Cytosolic glutathione S-transferases were purified from the epithelial cells of human small and large intestine. These preparations were characterized with regard to specific activities, subunit and isoenzyme composition. Isoenzyme composition and specific activity showed little variation from proximal to distal small intestine. Specific activities of hepatic and intestinal enzymes from the sam...
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ژورنال
عنوان ژورنال: Journal of Dairy, Veterinary & Animal Research
سال: 2017
ISSN: 2377-4312
DOI: 10.15406/jdvar.2017.05.00154